Medical Center of Health Science, Toranomon Hospital, Tokyo, Japan.
Metabolism. 2010 May;59(5):697-702. doi: 10.1016/j.metabol.2009.08.026. Epub 2009 Nov 14.
Various anthropometric indices have been proposed for metabolic syndrome. We investigated the clustering of metabolic risk factors other than components of metabolic syndrome and physical activity in subjects with and without metabolic syndrome as defined by different anthropometric indices. The subjects comprised 6141 men and 2137 women who underwent routine health examinations in Tokyo. We compared metabolic risk factors (high low-density lipoprotein cholesterol, hyperuricemia, high gamma-glutamyltransferase, fatty liver) and sedentary history in subjects with and without metabolic syndrome as defined by the American Heart Association by substituting various proposed anthropometric indices of abdominal obesity (waist circumference >or=85, >or=90, or >or=102 cm for men and >or=90, >or=80, or >or=88 cm for women; waist-to-height ratio >or=0.5 for both men and women). Irrespective of the anthropometric index or sex, the age-adjusted odds ratios for risk factors and sedentary history were all significantly greater in subjects with metabolic syndrome (men and women: 1.26 approximately 1.35 and 2.06 approximately 2.63 for high low-density lipoprotein cholesterol, 2.36 approximately 2.60 and 3.88 approximately 7.20 for hyperuricemia, 2.54 approximately 3.02 and 2.92 approximately 4.05 for high gamma-glutamyltransferase, 4.42 approximately 4.87 and 9.43 approximately 12.27 for fatty liver, and 1.37 approximately 1.50 and 1.43 approximately 1.72 for sedentary history). Findings still persisted in those not receiving medication for diabetes mellitus or coronary heart disease. Therefore, attention should be paid to other metabolic risk factors in subjects with metabolic syndrome, irrespective of the anthropometric index or sex. Further study is also needed to clarify the most appropriate definition of metabolic syndrome so as to include the spectrum of risk factors that best represents the future risk of cardiovascular and other diseases.
各种人体测量指标已被提出用于代谢综合征。我们研究了除代谢综合征成分和体力活动以外的代谢危险因素在根据不同人体测量指标定义的代谢综合征患者和无代谢综合征患者中的聚类。受试者包括在东京接受常规健康检查的 6141 名男性和 2137 名女性。我们比较了根据美国心脏协会定义的代谢综合征患者和无代谢综合征患者的代谢危险因素（高低密度脂蛋白胆固醇、高尿酸血症、高γ-谷氨酰转移酶、脂肪肝）和久坐史，用各种建议的腹部肥胖人体测量指标（男性腰围≥85、≥90 或≥102cm，女性腰围≥90、≥80 或≥88cm；男女腰围与身高比≥0.5）替代。无论人体测量指标或性别如何，代谢综合征患者的危险因素和久坐史的年龄调整比值比均显著更高（男性和女性：高低密度脂蛋白胆固醇为 1.26 至 1.35 和 2.06 至 2.63，高尿酸血症为 2.36 至 2.60 和 3.88 至 7.20，高γ-谷氨酰转移酶为 2.54 至 3.02 和 2.92 至 4.05，脂肪肝为 4.42 至 4.87 和 9.43 至 12.27，久坐史为 1.37 至 1.50 和 1.43 至 1.72）。在未服用糖尿病或冠心病药物的患者中，发现仍然存在。因此，无论人体测量指标或性别如何，都应关注代谢综合征患者的其他代谢危险因素。还需要进一步研究以阐明代谢综合征的最适当定义，以便纳入最能代表心血管和其他疾病未来风险的危险因素谱。
