Center for Research in Childhood Health, Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark, DK-5230 Odense, Denmark.
Metabolism. 2010 Apr;59(4):561-6. doi: 10.1016/j.metabol.2009.08.019. Epub 2009 Nov 14.
The aim was to evaluate the possible role of tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), C-reactive protein (CRP), low fitness, and fatness in the early development of clustering of cardiovascular disease (CVD) risk factors and insulin resistance. Subjects for this cross-sectional study were obtained from 18 schools near Copenhagen, Denmark. Two hundred ten 9-year-old children were selected for cytokine analysis from 434 third-grade children with complete CVD risk profiles. The subgroup was selected according to the CVD risk factor profile (upper and lower quartile of a composite CVD risk score). All the CVD risk factors and CRP differed between the high- and low-risk groups; but plasma glucose, TNF-alpha, and IL-6 had small and inconsistent differences. Strong associations were found between CVD risk scores and fitness (VO(2peak)) or fatness. No associations were found between CVD risk scores and TNF-alpha and IL-6. C-reactive protein was associated with fitness, fatness, and CVD risk score. This study does not support an association between plasma IL-6 or TNF-alpha and low insulin sensitivity or clustering of CVD risk factors in a young cohort. Inflammation was more pronounced in fat and unfit children based on the association with CRP levels. The association between fitness and fatness variables, insulin resistance, and clustered risk could be caused by other mechanisms related to these exposures. The role of IL-6 remains unclear.
目的在于评估肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、C 反应蛋白（CRP）、低体能和肥胖在心血管疾病（CVD）风险因素聚集和胰岛素抵抗的早期发展中的可能作用。本横断面研究的对象来自丹麦哥本哈根附近的 18 所学校。从 434 名具有完整 CVD 风险概况的三年级儿童中，选择了 210 名 9 岁儿童进行细胞因子分析。亚组是根据 CVD 风险因素概况（复合 CVD 风险评分的上下四分位数）选择的。所有 CVD 风险因素和 CRP 在高风险和低风险组之间存在差异；但是血糖、TNF-α和 IL-6的差异较小且不一致。CVD 风险评分与体能（VO(2peak)）或肥胖之间存在很强的相关性。CVD 风险评分与 TNF-α和 IL-6 之间无相关性。CRP 与体能、肥胖和 CVD 风险评分相关。本研究不支持在年轻人群中，血浆 IL-6 或 TNF-α与低胰岛素敏感性或 CVD 风险因素聚集之间存在关联。基于与 CRP 水平的关联，炎症在肥胖和体能不佳的儿童中更为明显。体能和肥胖变量、胰岛素抵抗和风险聚集之间的关联可能是由与这些暴露相关的其他机制引起的。IL-6 的作用仍不清楚。
