School of Physiology, Nutrition and Consumer Science, North-West University, Potchefstroom, South Africa.
Nutrition. 2010 Jan;26(1):90-9. doi: 10.1016/j.nut.2009.10.004.
The objective of this study was to compare the inflammatory status of children with differences in nutritional status.
This was a cross-sectional study of 184 African children aged 13-18 y from a low socioeconomic background that compared stunted with non-stunted and lean with over-fat (percentage of body fat above normal cutoff points) children. Fasting serum tumor necrosis factor-alpha, interleukin-6, C-reactive protein, and insulin were measured using high-sensitivity methods. Body composition was assessed using anthropometry and air-displacement plethysmography. T tests for parametric data and the Mann-Whitney test for non-parametric data were used to compare groups. Regression analyses and principal components analyses were done to assess relations between body composition and biochemical variables.
Of all participants 18% were stunted. Serum tumor necrosis factor-alpha of stunted girls was higher than in non-stunted girls. More of the stunted boys were over-fat compared with their non-stunted counterparts. Regression analyses showed that insulin resistance, diastolic blood pressure, and C-reactive protein contributed significantly to interleukin-6 in boys. Serum C-reactive protein, waist circumference, and body mass index clustered together in factor analysis in boys. Serum interleukin-6, waist-hip ratio, and tumor necrosis factor-alpha clustered together in factor analysis in girls.
An association between adiposity and stunting and between adiposity low-grade inflammation was found in this study. Interventions for stunted children focus mainly on correction of undernutrition by providing feeding schemes. Attention should, however, also be paid to changes in body composition over time to prevent excessive abdominal fat accumulation and risk for cardiovascular diseases later in life.
本研究旨在比较营养状况不同的儿童的炎症状态。
这是一项横断面研究，纳入了来自低社会经济背景的 184 名 13-18 岁的非洲儿童，比较了生长迟缓与非生长迟缓以及消瘦与超重（体脂百分比超过正常切点）儿童之间的差异。使用高灵敏度方法测量空腹血清肿瘤坏死因子-α、白细胞介素-6、C 反应蛋白和胰岛素。使用人体测量法和空气置换体积描记法评估身体成分。使用 t 检验进行参数数据比较，Mann-Whitney 检验进行非参数数据比较。进行回归分析和主成分分析，以评估身体成分与生化变量之间的关系。
所有参与者中，18%为生长迟缓。生长迟缓女孩的血清肿瘤坏死因子-α高于非生长迟缓女孩。与非生长迟缓的男孩相比，更多的生长迟缓男孩超重。回归分析显示，胰岛素抵抗、舒张压和 C 反应蛋白对男孩的白细胞介素-6有显著贡献。在男孩中，血清 C 反应蛋白、腰围和体重指数在因子分析中聚集在一起。在女孩中，血清白细胞介素-6、腰臀比和肿瘤坏死因子-α在因子分析中聚集在一起。
本研究发现肥胖与生长迟缓之间以及肥胖与低度炎症之间存在关联。针对生长迟缓儿童的干预措施主要集中在通过提供喂养方案来纠正营养不良。然而，还应注意身体成分随时间的变化，以防止腹部脂肪过度积累和日后患心血管疾病的风险。
