Department of Endocrinology, The First Clinical Hospital of Harbin Medical University, Harbin 150001, China.
Peptides. 2010 Feb;31(2):291-6. doi: 10.1016/j.peptides.2009.11.001. Epub 2009 Nov 13.
Obestatin is a recently discovered gastrointestinal hormone. It might play a role in the pathophysiology of obesity. We tried to investigate the expression of obestatin in gastric body mucosa in overweight (BMI>or=24 kg/m(2))/obese (BMI>or=28 kg/m(2)) patients. Thirty overweight/obese patients and 20 healthy controls were included in the study. Biopsy specimens of gastric mucosa were obtained from the middle body of the greater curvature. Obestatin expression in gastric mucosa was evaluated by immunohistochemistry. Fasting plasma obestatin levels were measured by radioimmunoassay. The number of obestatin-positive cells in gastric body mucosa was significantly lower in overweight and obese patients than that in healthy subjects. The plasma concentrations of obestatin were also decreased in overweight and obese patients. There was a positive correlation between the numbers of obestatin-positive cells in the gastric body mucosa and circulating obestatin levels. The results indicate that overweight and obese subjects have a reduction in the number of obestatin-positive cells in gastric body mucosa.
肥胖抑制素是一种新近发现的胃肠激素，可能在肥胖的病理生理学中发挥作用。我们试图研究超重（BMI≥24kg/m²）/肥胖（BMI≥28kg/m²）患者胃体黏膜中肥胖抑制素的表达。研究纳入 30 例超重/肥胖患者和 20 例健康对照者。取胃大弯中部胃黏膜活检标本，采用免疫组织化学方法检测胃黏膜中肥胖抑制素的表达，放射免疫法检测空腹血浆肥胖抑制素水平。与健康对照组相比，超重和肥胖患者胃体黏膜中肥胖抑制素阳性细胞的数量显著减少，血浆肥胖抑制素浓度也降低。胃体黏膜中肥胖抑制素阳性细胞的数量与循环中肥胖抑制素水平呈正相关。结果表明，超重和肥胖患者胃体黏膜中肥胖抑制素阳性细胞的数量减少。
