Lei Yi, Liang Yasha, Chen Yifan, Liu Xiaojing, Liao Xiaoyang, Luo Fengming
Department of Family Medicine, West China Hospital, Sichuan University, 37 GuoXue Xiang, Chengdu 610041, China.
Department of Respiratory Disease, West China Hospital, Sichuan University, 37 GuoXue Xiang, Chengdu 610041, China.
Multidiscip Respir Med. 2014 Jan 28;9(1):5. doi: 10.1186/2049-6958-9-5.
Some peptides, which regulate the metabolic balance, are thought to play important roles in nutritional disorders and systemic inflammation in COPD. Treatment of rats with obestatin decreased body-weight gain. Obestatin was also found to be correlated with inflammation in rheumatoid arthritis. The aims of this study were to investigate the level of circulating obestatin in COPD and to analyze the relationship among obestatin and nutritional status, and systemic inflammation.
32 COPD patients with BMI less than 20 kg/m2 and 22 normal controls were included. Body composition was estimated using "foot-to-foot" BIA technology. Circulating obestatin was determined with enzyme-linked immunosorbent assay. Pulmonary function, TNF-α and C reactive protein were also measured.
The level of circulating obestatin was higher in COPD with underweight than that in normal control (5562.75 ± 3435.43 pg/ml in COPD, 3663.90 ± 2313.95 pg/ml in controls, p = 0.028). BMI, Waist circumference, hip circumference, bodyFAT and FAT% in COPD group were lower than those in normal control. Positive correlation was found among circulating C reactive protein, TNF-α and obestatin. There was no significant correlation among BMI, pulmonary function and obestatin.
This study shows that circulating obestatin is higher in underweight COPD patients, and positively correlated to systemic inflammation, but not to nutritional status.
一些调节代谢平衡的肽被认为在慢性阻塞性肺疾病（COPD）的营养紊乱和全身炎症中起重要作用。用肥胖抑制素治疗大鼠可降低体重增加。肥胖抑制素也被发现与类风湿性关节炎中的炎症相关。本研究的目的是调查COPD患者循环中肥胖抑制素的水平，并分析肥胖抑制素与营养状况及全身炎症之间的关系。
纳入32例体重指数（BMI）小于20kg/m²的COPD患者和22名正常对照者。使用“足对足”生物电阻抗分析技术评估身体成分。采用酶联免疫吸附测定法测定循环中的肥胖抑制素。还测量了肺功能、肿瘤坏死因子-α（TNF-α）和C反应蛋白。
体重过轻的COPD患者循环中肥胖抑制素水平高于正常对照（COPD患者为5562.75±3435.43pg/ml，对照组为3663.90±2313.95pg/ml，p=0.028）。COPD组的BMI、腰围、臀围、体脂和脂肪百分比均低于正常对照组。循环中的C反应蛋白、TNF-α与肥胖抑制素呈正相关。BMI、肺功能与肥胖抑制素之间无显著相关性。
本研究表明，体重过轻的COPD患者循环中肥胖抑制素水平较高，且与全身炎症呈正相关，但与营养状况无关。
