Koller W C, Gehlmann L K, Malkinson F D, Davis F A
Arch Neurol. 1977 Oct;34(10):644-6. doi: 10.1001/archneur.1977.00500220078017.
Peripheral neuropathy is a rare complication of dapsone therapy. This neuropathy appears primarily to be of the motor type, and recovery occurs on discontinuation of the drug therapy. The patient in this report developed a marked motor deficit as well as a selective marked loss of vibration sense shortly after the initiation of a relatively low dose of dapsone. Recovery was rapid on cessation of the therapy. This patient was found to be a slow acetylator of isoniazid, and therefore is probably a slow acetylator of dapsone. The possible mechanisms of the neurotoxicity of dapsone and the role of altered metabolism are discussed.
周围神经病变是氨苯砜治疗的一种罕见并发症。这种神经病变主要表现为运动型，停药后可恢复。本报告中的患者在开始使用相对低剂量的氨苯砜后不久，出现了明显的运动功能缺损以及振动觉选择性明显丧失。停药后恢复迅速。该患者被发现是异烟肼慢乙酰化者，因此很可能也是氨苯砜慢乙酰化者。本文讨论了氨苯砜神经毒性的可能机制以及代谢改变的作用。
