Fredericks E J, Kugelman T P, Kirsch N
Arch Dermatol. 1976 Aug;112(8):1158-60. doi: 10.1001/archderm.112.8.1158.
A motor polyneuropathy developed in a woman with subcorneal pustular dermatosis of 16 years' duration, who had received at least 300 gm of dapsone over a five-year period and 80 gm during the four-month period of progression of her neurologic symptoms. Although the patient believed her muscle power had returned to normal four months after the drug was stopped, a slight peripheral neuropathy remained. Electrodiagnostic and clinical features during the period of greatest weakness and the subsequent 16 months were consistent with a polyneuropathy of the axonal type. The neurotoxicity of dapsone appears to be dose-dependent, but the mechanism by which it occurs is unknown.
一名患有持续16年的角层下脓疱性皮肤病的女性发生了运动性多发性神经病，她在五年期间至少服用了300克氨苯砜，在神经症状进展的四个月期间服用了80克。尽管患者认为停药四个月后肌肉力量已恢复正常，但仍残留轻度周围神经病。在肌无力最严重时期及随后16个月的电诊断和临床特征与轴索性多发性神经病相符。氨苯砜的神经毒性似乎与剂量有关，但其发生机制尚不清楚。
