Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia.
J Leukoc Biol. 2010 Feb;87(2):237-43. doi: 10.1189/jlb.0909608. Epub 2009 Nov 13.
A pore-forming protein, PRF, and serine proteases, Grz, are key effector molecules of CL. These toxins are stored within secretory granules, which exocytose their contents in response to immune synapse formation between the CL and virus-infected or transformed target cell. There, PRF and Grz synergize to induce various apoptotic death pathways and to maintain immune homeostasis. Mechanistic aspects of the synergy and apoptotic mechanisms are still not fully understood, and the current review will address some of the hotly debated controversies in the field.
一种形成孔的蛋白（PRF）和丝氨酸蛋白酶（Grz）是 CL 的关键效应分子。这些毒素储存在分泌颗粒中，当 CL 与病毒感染或转化的靶细胞之间形成免疫突触时，这些颗粒会将其内容物胞吐。在那里，PRF 和 Grz 协同作用诱导各种凋亡死亡途径，并维持免疫稳态。协同作用和凋亡机制的机制方面尚不完全清楚，本综述将讨论该领域一些有争议的热点问题。
