抗精子抗体对人精子与透明带及精子与卵细胞膜结合的抑制作用。
Inhibition of human sperm-zona pellucida and sperm-oolemma binding by antisperm antibodies.
作者信息
Liu D Y, Clarke G N, Baker H W
机构信息
Department of Obstetrics and Gynaecology, University of Melbourne, Royal Women's Hospital, Victoria, Australia.
出版信息
Fertil Steril. 1991 Feb;55(2):440-2.
The results of this preliminary investigation suggest that antisperm antibodies interfere predominantly with sperm-zona pellucida binding. The observation of similar numbers of control (Ab-) and test (Ab+) sperm bound to the oolemma implies that the antibody-mediated inhibition of capacitation, acrosome reaction, or oolemma binding may not be major causes of failed fertilization with sperm autoimmunity. However, only seven patients were studied, and further investigation with larger numbers of subjects are required.
这项初步调查结果表明，抗精子抗体主要干扰精子与透明带的结合。观察到与卵膜结合的对照（Ab-）和试验（Ab+）精子数量相似，这意味着抗体介导的对获能、顶体反应或卵膜结合的抑制可能不是精子自身免疫导致受精失败的主要原因。然而，仅研究了7名患者，需要对更多受试者进行进一步调查。
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