Ausin Israel, Mockler Todd C, Chory Joanne, Jacobsen Steven E
Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, California, USA.
Nat Struct Mol Biol. 2009 Dec;16(12):1325-7. doi: 10.1038/nsmb.1690. Epub 2009 Nov 15.
DNA methylation is an epigenetic mark affecting genes and transposons. Screening for mutants that fail to establish DNA methylation yielded two we termed "involved in de novo" (idn) 1 and 2. IDN1 encodes DMS3, an SMC-related protein, and IDN2 encodes a previously unknown double-stranded RNA-binding protein with homology to SGS3. IDN1 and IDN2 control de novo methylation and small interfering RNA (siRNA)-mediated maintenance methylation and are components of the RNA-directed DNA methylation pathway.
DNA甲基化是一种影响基因和转座子的表观遗传标记。筛选未能建立DNA甲基化的突变体产生了两个我们称为“参与从头合成”（idn）1和2的突变体。IDN1编码DMS3，一种与SMC相关的蛋白质，IDN2编码一种与SGS3具有同源性的先前未知的双链RNA结合蛋白。IDN1和IDN2控制从头甲基化和小干扰RNA（siRNA）介导的维持甲基化，并且是RNA指导的DNA甲基化途径的组成部分。
