Ledermann Walter, Valle Guido
Laboratorio de Microbiología, Hospital Luis Calvo Mackenna, Santiago de Chile.
Rev Chilena Infectol. 2009 Oct;26(5):466-71. Epub 2009 Nov 9.
Clinical research is absolutely necessary for the development of medical knowledge. However, progress of Medicine has not always been obtained respecting human rights. From 1880 onwards, after Laveran's discovery of the protozoan nature of malaria, the increase in knowledge on paludism has been remarkable. Much of the knowledge gained up to the middle of the twentieth century was based although on highly questionable experiments according to modern ethical standards in the fields of biology and physiopathology, and specially in therapeutic clinical trials with antimalarial drugs.
临床研究对于医学知识的发展绝对必要。然而，医学的进步并非总是在尊重人权的情况下取得的。自1880年以后，在拉韦朗发现疟疾的原生动物本质之后，关于疟疾的知识有了显著增长。直到20世纪中叶所获得的许多知识，尽管依据现代生物学和生理病理学领域的伦理标准，特别是在抗疟药物治疗性临床试验方面，是基于极有问题的实验。
