Classen S, McCarthy D P, Shechtman O, Awadzi K D, Lanford D N, Okun M S, Rodriguez R L, Romrell J, Bridges S, Kluger B, Fernandez H H
National Older Driver Research and Training Center, Department of Occupational Therapy, University of Florida, Gainesville, Florida, USA.
Traffic Inj Prev. 2009 Dec;10(6):593-8. doi: 10.1080/15389580903179901.
To determine the correlations of the Useful Field of View (UFOV), compared to other clinical tests of Parkinson's disease (PD); vision; and cognition with measures of on-road driving assessments and to quantify the UFOV's ability to indicate passing/failing an on-road test in people with PD.
Nineteen randomly selected people with idiopathic PD, mean age = 74.8 (6.1), 14 (73.7%) men, 18 (94.7%) Caucasians, were age-matched to 104 controls without PD. The controls had a mean age of 75.4 (6.4), 59 (56.7%) men, 96 (92.3%) Caucasians. Both groups were referred for a driving evaluation after institutional review board approval.
Compared to neuropsychological and clinical tests of vision and cognition, the UFOV showed the strongest correlations (r > .75, p < 0.05) with measures of failing a standardized road test and number of driving errors. Among PD patients, the UFOV Risk Index score of 3 (range 1-5) was established as the optimal cutoff value for passing the on-road test, with sensitivity 87 percent and specificity 82 percent, AUC = 92 percent (SE 0.61, p = .002). Similarly, the UFOV 2 (divided attention) optimum cutoff value is 223 ms (range 16-500 ms), sensitivity 87.5 percent, specificity 81.8 percent, AUC = 91 percent (SE 0.73, p = .003). The UFOV 3 (selected attention) optimal cutoff value is 273 ms (range 16-500 ms), sensitivity 75 percent, specificity 72.7 percent, AUC = 87 percent (SE 0.81, p = .007).
In this pilot study among PD patients, the UFOV may be a superior screening measure (compared to other measures of disease, cognition, and vision) for predicting on-road driving performance but its rigor must be verified in a larger sample of people with PD.
与帕金森病（PD）的其他临床测试、视力测试以及认知测试相比，确定有用视野（UFOV）与道路驾驶评估指标之间的相关性，并量化UFOV在指示PD患者道路测试通过/失败方面的能力。
随机选取19名特发性PD患者，平均年龄 = 74.8（6.1）岁，14名（73.7%）男性，18名（94.7%）白种人，与104名无PD的对照者进行年龄匹配。对照者的平均年龄为75.4（6.4）岁，59名（56.7%）男性，96名（92.3%）白种人。两组均在机构审查委员会批准后接受驾驶评估。
与视力和认知的神经心理学及临床测试相比，UFOV与标准化道路测试失败指标及驾驶错误数量的相关性最强（r >.75，p < 0.05）。在PD患者中，UFOV风险指数得分3（范围1 - 5）被确定为道路测试通过的最佳临界值，敏感性为87%，特异性为82%，曲线下面积（AUC） = 92%（标准误0.61，p =.002）。同样，UFOV 2（分心注意力）的最佳临界值为223毫秒（范围16 - 500毫秒），敏感性为87.5%，特异性为81.8%，AUC = 91%（标准误0.73，p =.003）。UFOV 3（选择性注意力）的最佳临界值为273毫秒（范围16 - 500毫秒），敏感性为75%，特异性为72.7%，AUC = 87%（标准误0.81，p =.007）。
在这项针对PD患者的初步研究中，与疾病、认知和视力的其他测量方法相比，UFOV可能是预测道路驾驶表现的更优筛查指标，但必须在更大规模的PD患者样本中验证其严谨性。
