Doyle A E
University of Melbourne, Department of Medicine, St. Vincent's Hospital, Fitzroy, Australia.
Hypertension. 1991 Feb;17(2):247-50. doi: 10.1161/01.hyp.17.2.247.
Sir Horace Smirk deserves much of the credit for establishing the benefits of reducing blood pressure. He was one of the main early proponents of the idea that it was the raised intra-arterial pressure itself that caused many of the cardiac and vascular complications of hypertension. His training in both pharmacology and internal medicine enabled him to devise practical methods for successful treatment of hypertension with ganglion blocking drugs such as hexamethonium. The major clinical benefits that followed such drug treatment proved a great stimulus to the development of drugs with fewer disadvantages and to widespread acceptance of the beneficial effects of antihypertensive drug treatment.
霍勒斯·斯莫克爵士在确立降低血压的益处方面功不可没。他是该理念的主要早期支持者之一，即动脉内压力升高本身会引发高血压的许多心脏和血管并发症。他在药理学和内科方面的培训使他能够设计出实用方法，用六甲铵等神经节阻断药物成功治疗高血压。这种药物治疗带来的主要临床益处极大地推动了缺点更少的药物的研发，以及抗高血压药物治疗有益效果的广泛认可。
