Wostyn Peter, Audenaert Kurt, De Deyn Peter Paul
Department of Psychiatry, PC Sint-Amandus, Reigerlostraat 10, 8730 Beernem, Belgium.
Cerebrospinal Fluid Res. 2009 Nov 16;6:14. doi: 10.1186/1743-8454-6-14.
In a recent article, elevated cerebrospinal fluid pressure (CSFP) consistent with very early normal pressure hydrocephalus (NPH), was found in a small subset of Alzheimer's disease (AD) patients (possible AD-NPH hybrids) enrolled in a clinical trial for chronic low-flow cerebrospinal fluid drainage. Also in the same study, was another interesting finding that merits further discussion: a substantial proportion of AD patients had very low CSFP. Based on the characteristics of these subjects, we hypothesize that more advanced AD may be associated with a decrease in CSFP. Reduced CSFP among a group of AD patients could provide a clue towards a better understanding of the high rate of comorbidity reported between AD and glaucoma since it has been shown that mean CSFP is lower in subjects with primary open-angle glaucoma. This could result in an abnormally high trans-lamina cribrosa pressure difference and lead to glaucomatous damage.
在最近一篇文章中，参与慢性低流量脑脊液引流临床试验的一小部分阿尔茨海默病（AD）患者（可能是AD-NPH混合型）被发现存在与极早期正常压力脑积水（NPH）相符的脑脊液压力升高（CSFP）。同样在该研究中，还有另一个值得进一步讨论的有趣发现：相当一部分AD患者的CSFP非常低。基于这些受试者的特征，我们推测更晚期的AD可能与CSFP降低有关。一组AD患者中CSFP降低可能为更好地理解AD与青光眼之间报告的高共病率提供线索，因为已经表明原发性开角型青光眼患者的平均CSFP较低。这可能导致筛板跨压差异异常高并导致青光眼性损伤。
