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BAX 和 BAK 被当场抓住。

BAX and BAK caught in the act.

机构信息

Burnham Institute for Medical Research, La Jolla, CA 92037, USA.

出版信息

Mol Cell. 2009 Nov 13;36(3):353-4. doi: 10.1016/j.molcel.2009.10.023.

Abstract

In this issue of Molecular Cell, Kim et al. (2009) describe the steps involved in the direct activation of the proapoptotic proteins BAX and BAK by their BH3-only partners, resolving the controversy regarding direct versus indirect activation of these proteins.

摘要

在本期《分子细胞》中,Kim 等人(2009)描述了其 BH3 仅蛋白伴侣直接激活促凋亡蛋白 BAX 和 BAK 所涉及的步骤,解决了关于这些蛋白直接激活还是间接激活的争议。

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本文引用的文献

1
Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.
Mol Cell. 2009 Nov 13;36(3):487-99. doi: 10.1016/j.molcel.2009.09.030.
2
Mapping the interaction of pro-apoptotic tBID with pro-survival BCL-XL.
Biochemistry. 2009 Sep 15;48(36):8704-11. doi: 10.1021/bi901171n.
3
BAX activation is initiated at a novel interaction site.
Nature. 2008 Oct 23;455(7216):1076-81. doi: 10.1038/nature07396.
4
The BCL-2 protein family: opposing activities that mediate cell death.
Nat Rev Mol Cell Biol. 2008 Jan;9(1):47-59. doi: 10.1038/nrm2308.
6
Structure of Bax: coregulation of dimer formation and intracellular localization.
Cell. 2000 Nov 10;103(4):645-54. doi: 10.1016/s0092-8674(00)00167-7.
7
Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis.
Science. 1997 Feb 14;275(5302):983-6. doi: 10.1126/science.275.5302.983.
8
Regulators of cell death.
Trends Genet. 1995 Mar;11(3):101-5. doi: 10.1016/S0168-9525(00)89010-1.
9
Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.
Br J Cancer. 1972 Aug;26(4):239-57. doi: 10.1038/bjc.1972.33.

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