肝移植后移植肝脂肪变性的逆转：前瞻性研究
Reversal of graft steatosis after liver transplantation: prospective study.
作者信息
Li J, Liu B, Yan L-N, Zuo Y-X, Li B, Zeng Y, Zhang S F, Li F-G
机构信息
Department of Anesthesiology and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
出版信息
Transplant Proc. 2009 Nov;41(9):3560-3. doi: 10.1016/j.transproceed.2009.06.222.
OBJECTIVE
To determine the risk factors for reversal of liver graft steatosis.
PATIENTS AND METHODS
This prospective study included 70 patients (47 men and 23 women) who received steatotic liver grafts between July 2003 and February 2008. No grafts from prisoners were used in the study. Patients were divided into 3 groups according to degree of liver steatosis, as follows: mild (n = 29, group 1), moderate (n = 23, group 2), and severe (n = 18, group 3).
RESULTS
The median (SD) degree of steatosis in liver grafts at transplantation was 15.7% (7.3%) in group 1, 26.3% (10.5%) in group 2, and 45.1% (8.3%) in group 3. Postoperative histologic analysis demonstrated dramatically decreased steatosis in all graft recipients.
CONCLUSION
Graft steatosis can be decreased substantially after liver transplantation. Factors for reversibility of steatosis include donor age, degree of macrovesicular steatosis, and cold ischemia time.
目的
确定肝移植脂肪变性逆转的危险因素。
患者与方法
这项前瞻性研究纳入了2003年7月至2008年2月期间接受脂肪变性肝移植的70例患者（47例男性和23例女性）。研究中未使用来自囚犯的移植物。根据肝脂肪变性程度将患者分为3组，如下：轻度（n = 29，第1组）、中度（n = 23，第2组）和重度（n = 18，第3组）。
结果
移植时肝移植物脂肪变性的中位数（标准差）程度在第1组为15.7%（7.3%），第2组为26.3%（10.5%），第3组为45.1%（8.3%）。术后组织学分析显示所有移植物受者的脂肪变性显著降低。
结论
肝移植后移植物脂肪变性可大幅降低。脂肪变性可逆的因素包括供体年龄、大泡性脂肪变性程度和冷缺血时间。
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