Wallinder Jonas, Skagius Elisabet, Bergqvist David, Henriksson Anders E
Department of Surgery, Sundsvall County Hospital, Sweden.
Vasc Endovascular Surg. 2010 Jan;44(1):32-5. doi: 10.1177/1538574409339358. Epub 2009 Nov 16.
Multiorgan failure is the main cause of death in patients operated for ruptured abdominal aortic aneurysm (rAAA). The systemic inflammatory response plays a central role in the generation and maintenance of multiorgan dysfunction. The aim of the current study was to investigate the inflammatory response preoperatively in patients with ruptured and nonruptured AAA in relation to the clinical outcome. A total of 95 patients about to undergo repair of AAA (43 ruptured with shock, 12 ruptured without shock, and 40 elective) and 41 controls without aneurysm matched by age, gender, and smoking habits were investigated by inflammatory markers. There were significantly higher levels of interleukin 6 (IL-6; proinflammatory cytokine) and IL-10 (anti-inflammatory cytokine) in patients operated for ruptured compared to nonruptured AAA. In conclusion, the current data indicate that rupture of an AAA activates the inflammatory system with a compensatory anti-inflammatory response.
多器官功能衰竭是腹主动脉瘤破裂（rAAA）手术患者死亡的主要原因。全身炎症反应在多器官功能障碍的发生和维持中起核心作用。本研究的目的是调查破裂性和非破裂性腹主动脉瘤患者术前的炎症反应与临床结局的关系。通过炎症标志物对95例即将接受腹主动脉瘤修复手术的患者（43例破裂伴休克、12例破裂无休克、40例择期手术）和41例年龄、性别和吸烟习惯相匹配的无动脉瘤对照者进行了调查。与非破裂性腹主动脉瘤手术患者相比，破裂性腹主动脉瘤手术患者的白细胞介素6（IL-6；促炎细胞因子）和IL-10（抗炎细胞因子）水平显著更高。总之，目前的数据表明，腹主动脉瘤破裂会激活炎症系统并伴有代偿性抗炎反应。
