Harris Debra J
Inpatient Adult Oncology and IV Therapy, Oregon Health & Science University, Woodburn, OR 97071, USA.
J Infus Nurs. 2009 Nov-Dec;32(6):323-9. doi: 10.1097/NAN.0b013e3181bd519e.
Granulocyte transfusion can be used as supportive therapy in patients with life-threatening neutropenia caused by bone marrow failure or in patients with neutrophil dysfunction. Emerging evidence demonstrates the benefits of granulocyte transfusions to treat infections in patients after treatment with high-dose chemotherapy, particularly the chemotherapy associated with conditioning for hematopoietic stem cell transplant. There has been an increased interest in the use of therapeutic granulocyte transfusion in recent years due to the ability to use granulocyte colony-stimulated factors to produce higher doses of granulocytes for transfusion. Other factors that influence the outcome of transfusion include the type of infection being treated, the likelihood of recipient marrow recovery, and recipient alloimmunization. This article provides a historical perspective on granulocyte transfusion and an overview of its clinical use.
粒细胞输注可作为骨髓衰竭所致危及生命的中性粒细胞减少患者或中性粒细胞功能障碍患者的支持性治疗。新出现的证据表明，粒细胞输注对接受大剂量化疗后患者的感染治疗有益，尤其是与造血干细胞移植预处理相关的化疗。近年来，由于能够使用粒细胞集落刺激因子来生产更高剂量的粒细胞用于输注，人们对治疗性粒细胞输注的兴趣有所增加。影响输注结果的其他因素包括所治疗感染的类型、受者骨髓恢复的可能性以及受者的同种免疫。本文提供了粒细胞输注的历史回顾及其临床应用概述。
