Strauss R G
Department of Pathology and Pediatrics, University of Iowa College of Medicine, Iowa City.
Hematol Oncol Clin North Am. 1994 Dec;8(6):1159-66.
Although the efficacy of therapeutic granulocyte transfusions as treatment for progressive infections in severely neutropenic patients is supported by the medical literature, this form of therapy is not widely accepted because it has been extremely difficult to transfuse an adequate dose of compatible granulocytes. Recently, the possibility has been raised to greatly increase the number of granulocytes collected by stimulating normal donors with recombinant granulocyte colony-stimulating factor. Accordingly, it is reasonable to reassess the possible role for granulocyte transfusions as therapy for progressive bacterial, yeast, and fungal infections.
尽管医学文献支持治疗性粒细胞输注对严重中性粒细胞减少患者进行性感染的疗效，但这种治疗形式并未被广泛接受，因为输注足够剂量的相容粒细胞极其困难。最近，通过用重组粒细胞集落刺激因子刺激正常供体来大幅增加收集的粒细胞数量的可能性已经出现。因此，重新评估粒细胞输注作为治疗进行性细菌、酵母和真菌感染的可能作用是合理的。
