Lee Jennifer
Veterans Affairs Long Beach Healthcare System, 5701 E 7th St, Long Beach, CA 90822, USA.
J Infus Nurs. 2009 Nov-Dec;32(6):330-5. doi: 10.1097/NAN.0b013e3181bd5373.
Bisphosphonates are synthetic analogs of naturally occurring pyrophosphates, and they inhibit osteoclast-mediated bone resorption. They are widely used for the prevention and treatment of osteoporosis, treatment of Paget's disease of bone, management of metastatic cancer in bone, and short-term management of acute hypercalcemia. Osteonecrosis of the jaw is an adverse drug effect of bisphosphonates, and it typically presents as infection and necrotic bone in the mandible or maxilla. This article discusses pharmacology of bisphosphonates and osteonecrosis of the jaw, including its contributing factors, pathophysiology, prevention, and management, as well as appropriate nursing interventions.
双膦酸盐是天然焦磷酸盐的合成类似物，可抑制破骨细胞介导的骨吸收。它们广泛用于预防和治疗骨质疏松症、治疗骨Paget病、管理骨转移癌以及急性高钙血症的短期管理。颌骨坏死是双膦酸盐的一种药物不良反应，通常表现为下颌骨或上颌骨的感染和坏死骨。本文讨论双膦酸盐的药理学和颌骨坏死，包括其促成因素、病理生理学、预防和管理，以及适当的护理干预措施。
