双膦酸盐与骨坏死：潜在的治疗方法还是严重的并发症？

Bisphosphonates and osteonecrosis: potential treatment or serious complication?

作者信息

Goytia Robin N, Salama Andrew, Khanuja Harpal S

机构信息

Johns Hopkins Orthopaedics at Good Samaritan Hospital, 5601 Loch Raven Boulevard, Professional Office Building, Suite G-1, Baltimore, MD 21239, USA.

出版信息

Orthop Clin North Am. 2009 Apr;40(2):223-34. doi: 10.1016/j.ocl.2008.12.002.

DOI:10.1016/j.ocl.2008.12.002

PMID:19358907

Abstract

They are commonly used to treat osteoporosis and other diseases that involve osteoclast-mediated bone resorption, including Paget's disease and multiple myeloma. Their use in treating osteonecrosis of the femoral head has been studied and theoretically holds promise. There are complications associated with these medications, however, including the development of osteonecrosis in the jaw.

摘要

它们通常用于治疗骨质疏松症和其他涉及破骨细胞介导的骨吸收的疾病，包括佩吉特氏病和多发性骨髓瘤。它们在治疗股骨头坏死方面的应用已得到研究，理论上有前景。然而，这些药物存在一些并发症，包括颌骨坏死的发生。