Emory University Wound Ostomy and Continence Nursing Education Program, Atlanta, Georgia, USA.
J Wound Ostomy Continence Nurs. 2009 Nov-Dec;36(6 Suppl):S4-11. doi: 10.1097/WON.0b013e3181bfdf83.
Debridement is an essential component of wound bed preparation. Various techniques of debridement are commonly used in clinical practice. This systematic review summarizes and ranks evidence concerning the safety and efficacy of the selective enzymatic debriding agent collagenase. Studies were identified comparing collagenase to inactive (sham) ointment and to alternate techniques for debridement including autolytic and surgical. A preponderance of evidence from this systematic review confirms that collagenase ointment is a safe and effective choice for debridement of cutaneous ulcers and burn wounds.
清创术是创面准备的重要组成部分。在临床实践中，有多种清创技术被广泛应用。本系统综述对胶原酶选择性酶解清创剂的安全性和有效性进行了总结和分级，纳入的研究比较了胶原酶与非活性（假）软膏及其他清创技术（包括自溶性和手术性清创）的效果。本系统综述的大量证据证实，胶原酶软膏是皮肤溃疡和烧伤创面清创的安全有效选择。
