Department of Geriatric Medicine, University Medical Centre Utrecht, GA Utrecht, The Netherlands.
Menopause. 2010 Mar;17(2):309-14. doi: 10.1097/gme.0b013e3181bd54df.
The aim of this study was to examine the effects of raloxifene compared with those of placebo on verbal memory, mental processing speed, depression, anxiety, and quality of life.
A randomized, double-blind, placebo-controlled trial of 213 healthy women 70 years or older was conducted between July 2003 and January 2008 at the University Medical Centre Utrecht, the Netherlands. Participants were randomly assigned to receive raloxifene (60 mg) or placebo daily for 12 months. Measurements were taken at baseline and after 3, 6, and 12 months. The change in scores from baseline was calculated. The main outcome measures were direct and delayed verbal memory (Groningen 15 Words test), mental processing speed (Trails B test), mood/depression (Geriatric Depression Scale), anxiety (State-Trait Anxiety Inventory 1 and 2), and quality of life (Women's Health Questionnaire and EuroQol-5 dimensional questionnaire).
Direct verbal memory improved significantly with raloxifene compared with placebo: the women receiving raloxifene repeated more words in the words A + B test than did the women receiving placebo (P = 0.025). At 12 months, the change from baseline was 16 words in the raloxifene group and 10 words in the placebo group. In the words A test, direct repetition was also significantly better among women receiving raloxifene than among women receiving placebo (P = 0.023), with the change from baseline in the number of words repeated being nine words in the raloxifene group and six words in the placebo group at 12 months.
In postmenopausal women, raloxifene gave significantly improved verbal memory when compared with placebo.
本研究旨在考察雷洛昔芬与安慰剂相比对言语记忆、心理加工速度、抑郁、焦虑和生活质量的影响。
2003 年 7 月至 2008 年 1 月，在荷兰乌得勒支大学医学中心进行了一项针对 213 名 70 岁或以上健康女性的随机、双盲、安慰剂对照试验。参与者被随机分配接受雷洛昔芬（60 毫克）或安慰剂，每天一次，持续 12 个月。在基线时以及 3、6 和 12 个月时进行测量。从基线计算得分变化。主要观察指标为直接和延迟言语记忆（格罗宁根 15 词测试）、心理加工速度（轨迹 B 测试）、情绪/抑郁（老年抑郁量表）、焦虑（状态-特质焦虑量表 1 和 2）和生活质量（妇女健康问卷和 EuroQol-5 维度问卷）。
与安慰剂相比，雷洛昔芬治疗后言语记忆明显改善：服用雷洛昔芬的女性在 A + B 测试中重复的单词比服用安慰剂的女性多（P = 0.025）。在 12 个月时，雷洛昔芬组的变化从基线增加了 16 个单词，而安慰剂组增加了 10 个单词。在 A 测试中，服用雷洛昔芬的女性的直接重复也明显优于服用安慰剂的女性（P = 0.023），服用雷洛昔芬的女性的重复单词数量从基线变化了 9 个单词，而安慰剂组的变化为 6 个单词，在 12 个月时。
在绝经后妇女中，雷洛昔芬与安慰剂相比，言语记忆显著改善。
