Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Spinal Cord. 2010 May;48(5):429-33. doi: 10.1038/sc.2009.145. Epub 2009 Nov 17.
To investigate the relationship between medications known to cause fatigue in spinal cord injury (SCI) and fatigue severity and to describe the pattern of prescription of these medications.
Retrospective chart review.
GF Strong Rehabilitation Centre, Vancouver, British Columbia, Canada.
Medical charts of 136 individuals admitted to the GF Strong Outpatient SCI Program between December 2004 and May 2007 were reviewed. Data collected included information on medications, clinical and demographic characteristics and Fatigue Severity Scale (FSS) scores. Multiple linear regression techniques were used to analyse the data.
Fifty-two percent of the subjects had clinically relevant fatigue. As a group, the subjects were taking 147 different medications; 41/147 medications were identified as causing fatigue. The two most commonly prescribed categories of medications were antispasticity medications (75 subjects) and analgesic medications (61 subjects). Although several variables were found to contribute to the FSS scores including the use of fatigue-causing medications, the presence of pain (7.6% of variance) and the use of fatigue-causing analgesics (4.2% of variance) explained the most variance in the scores.
Fatigue is prevalent in outpatients with SCI. Fatigue-causing medications contribute to a higher FSS score. Clinicians treating persons with SCI should be aware that fatigue is a common and significant problem. Clinicians should be aware that fatigue may be exacerbated by the use of medication and should enquire about the effects of medication on fatigue when assessing and prescribing new medications.
研究已知会导致脊髓损伤（SCI）患者疲劳的药物与疲劳严重程度之间的关系，并描述这些药物的处方模式。
回顾性图表审查。
加拿大不列颠哥伦比亚省温哥华 GF 坚强康复中心。
对 2004 年 12 月至 2007 年 5 月期间入住 GF 坚强门诊 SCI 项目的 136 名个体的医疗图表进行了审查。收集的数据包括药物信息、临床和人口统计学特征以及疲劳严重程度量表（FSS）评分。采用多元线性回归技术分析数据。
52%的受试者存在临床相关疲劳。作为一个群体，受试者共服用 147 种不同的药物；确定 41/147 种药物会导致疲劳。最常开的两类药物是抗痉挛药物（75 名受试者）和镇痛药物（61 名受试者）。尽管发现了几个变量会影响 FSS 评分，包括使用会导致疲劳的药物、存在疼痛（占方差的 7.6%）和使用会导致疲劳的镇痛药（占方差的 4.2%），但这两个变量对评分的解释程度最高。
脊髓损伤门诊患者普遍存在疲劳。导致疲劳的药物会导致 FSS 评分更高。治疗脊髓损伤患者的临床医生应该意识到疲劳是一个常见且严重的问题。临床医生应该意识到，疲劳可能会因使用药物而加剧，并且在评估和开新药时应询问药物对疲劳的影响。
