Prostate Research Group, The Chancellors Building, University of Edinburgh, Edinburgh, UK.
Prostate Cancer Prostatic Dis. 2010 Mar;13(1):94-6. doi: 10.1038/pcan.2009.49. Epub 2009 Nov 17.
Fibroblast growth factor receptor 4 (FGFR4), a member of the fibroblast growth receptor family, was recently reported to be more abundantly expressed in malignant than benign prostate cells. A single nucleotide polymorphism at position 388 of the FGFR4 amino-acid sequence results in the substitution of glycine (Gly) with arginine (Arg) and higher frequency of the ArgArg genotype was previously found in prostate cancer patients. DNA was extracted from the blood drawn from 399 prostate cancer patients, 150 BPH patients and 294 healthy community controls. Polymerase chain reaction was carried out and single nucleotide polymorphisms of FGFR4 were identified by restriction enzyme digestion. No overall association is detectable between the Arg allele and increased prostate cancer risk. Subgroup analysis shows a higher incidence of the heterozygous ArgGly genotype in cancer cases than in the combined group of BPH and controls (P<0.05); this difference is statistically significant between cancer and BPH patients but not between cancer cases and community controls. The single nucleotide polymorphism Gly(388)Arg in FGFR4 is not associated with increased risk of prostate cancer in Scottish men. This observation is in contrast with results from two previous studies conducted in the USA and Japan.
成纤维细胞生长因子受体 4（FGFR4）是成纤维细胞生长因子受体家族的成员，最近有报道称其在恶性前列腺细胞中的表达比良性前列腺细胞更为丰富。FGFR4 氨基酸序列第 388 位的单核苷酸多态性导致甘氨酸（Gly）被精氨酸（Arg）取代，先前在前列腺癌患者中发现 ArgArg 基因型的频率更高。从 399 名前列腺癌患者、150 名 BPH 患者和 294 名健康社区对照者的血液中提取 DNA。通过聚合酶链反应进行，并通过限制性内切酶消化鉴定 FGFR4 的单核苷酸多态性。Arg 等位基因与前列腺癌风险增加之间没有可检测到的总体关联。亚组分析显示，癌症病例中杂合子 ArgGly 基因型的发生率高于 BPH 和对照组的组合（P<0.05）；这种差异在癌症和 BPH 患者之间具有统计学意义，但在癌症病例和社区对照者之间没有统计学意义。FGFR4 中的单核苷酸多态性 Gly(388)Arg 与苏格兰男性前列腺癌风险的增加无关。这一观察结果与之前在美国和日本进行的两项研究的结果相反。
