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男性尿失禁:患病率、危险因素及预防干预措施

Male urinary incontinence: prevalence, risk factors, and preventive interventions.

作者信息

Shamliyan Tatyana A, Wyman Jean F, Ping Ryan, Wilt Timothy J, Kane Robert L

出版信息

Rev Urol. 2009 Summer;11(3):145-65.

PMID:19918340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2777062/
Abstract

Urinary incontinence (UI) in community-dwelling men affects quality of life and increases the risk of institutionalization. Observational studies and randomized, controlled trials published in English from 1990 to November 2007 on the epidemiology and prevention of UI were identified in several databases to abstract rates and adjusted odds ratios (OR) of incontinence, calculate absolute risk difference (ARD) after clinical interventions, and synthesize evidence with random-effects models. Of 1083 articles identified, 126 were eligible for analysis. Pooled prevalence of UI increased with age to 21% to 32% in elderly men. Poor general health, comorbidities, severe physical limitations, cognitive impairment, stroke (pooled OR 1.54; 95% confidence interval [CI], 1.14-2.1), urinary tract infections (pooled OR 3.49; 95% CI, 2.33-5.23), prostate diseases, and diabetes (pooled OR 1.36; 95% CI, 1.14-1.61) were associated with UI. Treatment with tolterodine alone (ARD 0.17; 95% CI, 0.02-0.32) or combined with tamsulosin (ARD 0.17; 95% CI, 0.08-0.25) resulted in greater self-reported benefit compared with placebo. Radical prostatectomy or radiotherapy for prostate cancer compared with watchful waiting increased UI. Short-term prevention of UI with pelvic floor muscle rehabilitation after prostatectomy was not consistently seen across randomized, controlled trials. The prevalence of incontinence increased with age and functional dependency. Stroke, diabetes, poor general health, radiation, and surgery for prostate cancer were associated with UI in community-dwelling men. Men reported overall benefit from drug treatments. Limited evidence of preventive effects of pelvic floor rehabilitation requires future investigation.

摘要

社区居住男性的尿失禁会影响生活质量,并增加入住养老院的风险。通过在多个数据库中检索1990年至2007年11月期间以英文发表的关于尿失禁流行病学和预防的观察性研究及随机对照试验,提取失禁率和调整后的比值比(OR),计算临床干预后的绝对风险差异(ARD),并采用随机效应模型综合证据。在检索到的1083篇文章中,有126篇符合分析条件。老年男性尿失禁的合并患病率随年龄增长升至21%至32%。总体健康状况差、合并症、严重身体功能受限、认知障碍、中风(合并OR 1.54;95%置信区间[CI],1.14 - 2.1)、尿路感染(合并OR 3.49;95% CI,2.33 - 5.23)、前列腺疾病和糖尿病(合并OR 1.36;95% CI,1.14 - 1.61)与尿失禁相关。与安慰剂相比,单独使用托特罗定治疗(ARD 0.17;95% CI,0.02 - 0.32)或与坦索罗辛联合使用(ARD 0.17;95% CI,0.08 - 0.25)能带来更高的自我报告获益。与密切观察相比,前列腺癌根治术或放疗会增加尿失禁风险。前列腺切除术后通过盆底肌肉康复进行尿失禁的短期预防在随机对照试验中结果并不一致。尿失禁患病率随年龄和功能依赖程度增加。中风、糖尿病、总体健康状况差、放疗以及前列腺癌手术与社区居住男性的尿失禁相关。男性报告称药物治疗总体有益。盆底康复预防效果的证据有限,需要未来进一步研究。

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Outcomes of patients who participate in randomised controlled trials compared to similar patients receiving similar interventions who do not participate.与接受类似干预但未参与的类似患者相比,参与随机对照试验的患者的结局。
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