Di Bernardo Giovanni, Galderisi Umberto, Fiorito Carmela, Squillaro Tiziana, Cito Letizia, Cipollaro Marilena, Giordano Antonio, Napoli Claudio
Department of Experimental Medicine, Biotechnology and Molecular Biology Section, Second University of Naples, Naples, Italy.
J Cell Physiol. 2010 Feb;222(2):474-80. doi: 10.1002/jcp.21976.
Hematopoietic stem cells derive regulatory information also from parathyroid hormone (PTH). To explore the possibility that PTH may have a role in regulation of other stem cells residing in bone marrow, such as mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) we assessed the effect of this hormone on the in vitro behavior of MSCs and EPCs. We evidenced that MSCs were much more responsive to PTH than EPCs. PTH increased the proliferation rate of MSCs with a diminution of senescence and apoptosis. Taken together, our results may suggest a protective effect of PTH on MSCs that reduces stress phenomena and preserve genome integrity. At the opposite, PTH did not modify the fate of EPCs in culture.
造血干细胞也从甲状旁腺激素（PTH）中获取调节信息。为了探究PTH可能在调节骨髓中其他干细胞（如间充质干细胞（MSC）和内皮祖细胞（EPC））方面发挥作用的可能性，我们评估了这种激素对MSC和EPC体外行为的影响。我们证明，MSC对PTH的反应比EPC更强烈。PTH提高了MSC的增殖率，同时衰老和凋亡减少。综上所述，我们的结果可能表明PTH对MSC具有保护作用，可减少应激现象并维持基因组完整性。相反，PTH并未改变培养中EPC的命运。
