光敏菌素 A-F，来源于植物内生真菌拟盘多毛孢的具有细胞毒性的苯并呋喃酮衍生的γ-内脂。

Photinides A-F, cytotoxic benzofuranone-derived gamma-lactones from the plant endophytic fungus Pestalotiopsis photiniae.

机构信息

Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, People's Republic of China.

出版信息

J Nat Prod. 2009 May 22;72(5):942-5. doi: 10.1021/np900084d.

DOI:10.1021/np900084d

PMID:19371070

Abstract

Photinides A-F (1-6), six new unique benzofuranone-derived gamma-lactones, have been isolated from the crude extract of the plant endophytic fungus Pestalotiopsis photiniae. The structures of these compounds were elucidated primarily by NMR spectroscopy, and their absolute configurations were assigned by application of the CD excitation chirality method. Compounds 1-6 displayed modest cytotoxic effects against the human tumor cell line MDA-MB-231.

摘要

Photinides A-F（1-6），六种新型独特的苯并呋喃酮衍生的γ-内酯，从植物内生真菌 Pestalotiopsis photiniae 的粗提物中分离得到。这些化合物的结构主要通过 NMR 光谱学阐明，并通过应用 CD 激发手性方法确定其绝对构型。化合物 1-6 对人肿瘤细胞系 MDA-MB-231 表现出适度的细胞毒性作用。