Department of Cellular Pathology, Southmead Hospital, Bristol, UK.
Histopathology. 2009 Dec;55(6):705-8. doi: 10.1111/j.1365-2559.2009.03437.x.
To describe the histopathological features of a series of patients with ketamine-related cystitis.
Seventeen patients with ketamine-related cystitis, who had undergone biopsy, were identified and reviewed. Twelve showed ulceration with significant urothelial atypia. In 10 of these, immunohistochemistry was performed; 9/10 had high p53 immunoreactivity and 7/10 had moderate to high levels of Ki67 reactivity, but all were negative for cytokeratin 20.
Ketamine can lead to reactive urothelial changes that can mimic carcinoma in situ, but the long-term cancer risk remains unknown.
描述一系列与氯胺酮相关膀胱炎患者的组织病理学特征。
共确定并回顾了 17 例接受活检的氯胺酮相关膀胱炎患者。12 例表现为溃疡伴显著的尿路上皮异型性。其中 10 例进行了免疫组织化学检查；10/9 例 p53 免疫反应强阳性，7/10 例 Ki67 反应呈中高强度，但所有病例的细胞角蛋白 20 均为阴性。
氯胺酮可导致反应性尿路上皮变化，这些变化类似于原位癌，但长期的癌症风险尚不清楚。
