循环性脑反应自身抗体与中枢神经系统狼疮 MRL 模型中的行为缺陷。
Circulating brain-reactive autoantibodies and behavioral deficits in the MRL model of CNS lupus.
机构信息
Neuroimmunology Labs, School of Life Sciences, Arizona State University, Tempe, AZ 85287-4501 USA.
出版信息
J Neuroimmunol. 2010 Jan 25;218(1-2):73-82. doi: 10.1016/j.jneuroim.2009.10.008. Epub 2009 Nov 17.
Abstract
Brain-reactive autoantibodies (BRAA) are hypothesized to play a role in the neuropsychiatric manifestations that accompany systemic lupus erythematosus (SLE). The present study tests the proposed relation between circulating BRAA and behavioral deficits in lupus-prone MRL/lpr mice. Two age-matched cohorts born at different times were used to test the relationship in the context of altered disease severity. Significant correlations between autoimmunity and behavior were detected in both cohorts. These results are the first to report correlations between behavior and autoantibodies to integral membrane proteins of brain, supporting the hypothesis that BRAA contribute to the behavioral dysfunction seen in lupus.
摘要
脑反应性自身抗体（BRAA）被假设在伴随系统性红斑狼疮（SLE）的神经精神表现中发挥作用。本研究测试了循环 BRAA 与狼疮易感 MRL/lpr 小鼠行为缺陷之间的拟议关系。使用两个在不同时间出生的年龄匹配队列来测试在疾病严重程度改变的情况下的关系。在两个队列中都检测到自身免疫与行为之间的显著相关性。这些结果是首次报告脑膜整合蛋白的自身抗体与行为之间的相关性，支持 BRAA 导致狼疮中所见的行为功能障碍的假说。
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