Margutti Paola, Delunardo Federica, Ortona Elena
Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità, Rome, Italy.
Curr Neurovasc Res. 2006 May;3(2):149-57. doi: 10.2174/156720206776875894.
Growing evidence suggests that autoantibodies to neuronal or endothelial targets in psychiatric disorders exist and may be pathogenic. This review describes and discusses the possible role of autoantibodies related to the psychiatric manifestations in autoimmune diseases, autoantibodies related to the psychiatric disorders present in post-streptococcal diseases, celiac disease, chronic fatigue syndrome and substance abuse, and autoantibodies related to schizophrenia and autism, disorders now considered of autoimmune origin.
越来越多的证据表明,精神疾病中存在针对神经元或内皮靶点的自身抗体,并且可能具有致病性。本综述描述并讨论了自身抗体在自身免疫性疾病中与精神症状相关的可能作用、与链球菌感染后疾病、乳糜泻、慢性疲劳综合征及药物滥用中出现的精神疾病相关的自身抗体,以及与精神分裂症和自闭症相关的自身抗体,这些疾病目前被认为具有自身免疫起源。