Department of Microbiology, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo 060-8556, Japan.
J Neuroimmunol. 2010 Jan 25;218(1-2):129-33. doi: 10.1016/j.jneuroim.2009.10.009.
Anti-heat shock protein 70 (HSP70) autoantibodies are found in cerebrospinal fluids (CSF) from patients with multiple sclerosis. These autoantibodies cross-reacted not only with HSP70 and heat shock cognate protein 70 (HSC70), but also with a bacterial homologue, DnaK. CSF with a high anti-HSP70 autoantibody titer enhanced HSP70-induced proinflammatory cytokine and chemokine production in the human monocytic cell line, THP-1. Thus, anti-HSP70 autoantibodies in the CSF of multiple sclerosis patients may play a pathophysiological role in enhancing inflammation.
抗热休克蛋白 70（HSP70）自身抗体存在于多发性硬化症患者的脑脊液（CSF）中。这些自身抗体不仅与 HSP70 和热休克同源蛋白 70（HSC70）发生交叉反应，而且还与细菌同源物 DnaK 发生交叉反应。CSF 中具有高抗 HSP70 自身抗体滴度的 CSF 增强了 HSP70 诱导的人单核细胞系 THP-1 中促炎细胞因子和趋化因子的产生。因此，多发性硬化症患者 CSF 中的抗 HSP70 自身抗体可能在增强炎症中发挥病理生理作用。
