Department of Perinatology, National Center for Child Health and Development, Tokyo, Japan.
Eur J Clin Nutr. 2010 Feb;64(2):221-3. doi: 10.1038/ejcn.2009.125. Epub 2009 Nov 18.
Iron deficiency is the most common cause of anemia in pregnancy. Pregnant women with anemia are, in general, exclusively treated with iron supplementation. We observed that several pregnant women with anemia who were nonresponsive to iron supplementation also had vitamin B6 deficiency, and that anemia in these cases improved with the administration of vitamin B6. Our prospective study in healthy pregnant women showed that blood levels of iron, ferritin and vitamin B6, in particular, fell to the lower limit of the nonpregnant reference range by the third trimester. We conclude that it is important to take into account the deficiency of vitamin B6 besides iron in the evaluation of anemia during pregnancy.
缺铁是妊娠期贫血最常见的原因。一般来说，患有贫血的孕妇仅接受铁补充治疗。我们观察到，一些对铁补充治疗无反应的贫血孕妇也存在维生素 B6 缺乏，而这些情况下给予维生素 B6 治疗可改善贫血。我们在健康孕妇中的前瞻性研究表明，到妊娠晚期，铁、铁蛋白和维生素 B6 等血液水平尤其降至非妊娠参考范围的下限。我们的结论是，在评估妊娠期贫血时，除了铁之外，还应考虑到维生素 B6 的缺乏。
