通过与水解反应过渡态类似物的结合测定，从肽缩醛环芳烃文库中发现水解催化剂。
Discovery of hydrolytic catalysts in a peptidocalixarene library by binding assay with a transition state analogue for the hydrolysis.
机构信息
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
出版信息
Chem Commun (Camb). 2009 Dec 14(46):7194-6. doi: 10.1039/b913907a. Epub 2009 Oct 15.
DOI:10.1039/b913907a
PMID:19921027
Abstract
Hydrolytic catalysts were found in a peptidocalixarene library by binding assay with a transition state analogue for the hydrolysis. The rate of the reaction can be specifically enhanced up to 50-fold in the presence of the discovered catalyst.
摘要
通过与水解的过渡态类似物的结合分析，在肽缩醛笼文库中发现了水解催化剂。在发现的催化剂存在下，反应速率可以特异性地提高 50 倍。
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