通过一种新型 Ugi 产物的脱氢氟反应，温和高效地合成单氟代α-内酰胺假肽。

A mild and efficient synthesis of monofluorinated α-lactam pseudopeptides via a novel dehydrofluorination of Ugi products.

机构信息

Shanghai Key Laboratory of Chemical Biology, Center of Fluorine Chemical Technology, School of Pharmacy, East China University of Science and Technology, 200237, Shanghai, China.

出版信息

Mol Divers. 2010 Aug;14(3):501-6. doi: 10.1007/s11030-009-9209-x. Epub 2009 Nov 17.

DOI:10.1007/s11030-009-9209-x

PMID:19921454

Abstract

Six novel monofluorinated α-lactam pseudopeptide derivatives were synthesized via Ugi reaction using gem-difluoromethylene-containing isocyanide as a key component, followed by dehydrofluorination of Ugi products in one pot without additional base.

摘要

通过 Ugi 反应，使用含偕二氟亚甲基的异氰化物作为关键组分，合成了 6 种新型单氟化α-内酰胺假肽衍生物，然后在一锅反应中无需额外碱进行 Ugi 产物的脱氢氟化反应。