通过顺序 Ugi 反应高效进入肼肽样结构。

Efficient entry into hydrazinopeptide-like structures via sequential Ugi reactions.

机构信息

Chemical Diversity Research Institute, 2a Rabochaya St, 114401 Khimki, Moscow Region, Russia.

出版信息

Mol Divers. 2010 Aug;14(3):493-9. doi: 10.1007/s11030-009-9200-6. Epub 2009 Nov 10.

PMID:19902373

Abstract

Novel types of hydrazinopeptide-like units containing five elements of diversity have been prepared in two steps using sequential Ugi reactions.

摘要

已通过两步连续 Ugi 反应，制备了含有 5 种多样性元素的新型酰肼肽样单元。

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A mimicry of primary amines by bis-secondary diamines as components in the Ugi four-component reaction.

Angew Chem Int Ed Engl. 2006 Feb 6;45(7):1099-102. doi: 10.1002/anie.200503095.

Design and synthesis of hydrazinopeptides and their evaluation as human leukocyte elastase inhibitors.

J Med Chem. 1998 Nov 19;41(24):4833-43. doi: 10.1021/jm980419o.

Crystal structure analysis of a beta-turn mimic in hydrazino peptides.

Int J Pept Protein Res. 1994 Mar;43(3):305-11. doi: 10.1111/j.1399-3011.1994.tb00395.x.

[UGI reaction with hydrazines, II].

Arch Pharm Ber Dtsch Pharm Ges. 1971 Dec;304(12):933-43. doi: 10.1002/ardp.19713041212.

[On understanding the Ugi reaction with hydraxines. I].

Arch Pharm Ber Dtsch Pharm Ges. 1966 Sep;299(9):746-56. doi: 10.1002/ardp.19662990903.

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通过顺序 Ugi 反应高效进入肼肽样结构。

Efficient entry into hydrazinopeptide-like structures via sequential Ugi reactions.

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通过顺序 Ugi 反应高效进入肼肽样结构。

Efficient entry into hydrazinopeptide-like structures via sequential Ugi reactions.

机构信息

出版信息

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