Department of Psychiatry, University of California, La Jolla, California 92093, USA.
Hippocampus. 2010 Dec;20(12):1366-75. doi: 10.1002/hipo.20722.
Memories are initially stored in a labile state and are subject to modification by a variety of treatments, including disruption of hippocampal function. We infused a sodium channel blocker (or CNQX) to inactivate the rat dorsal hippocampus reversibly for 1 week following training on a task of spatial memory (the water maze). Previous work with conventional lesions has established that the dorsal hippocampus is essential for both the acquisition and expression of memory in this task. The question in the present study was whether chronic disruption of neuronal activity in the dorsal hippocampus after training would abolish memory or whether memory would survive extended disruption of hippocampal activity. As expected from earlier work, we found that performance was impaired during the infusion period. The critical test occurred 1 week after the lesion was reversed. We found that retention of the water maze recovered to control levels. Accordingly, sustained hippocampal activity following training is not obligatory for either the maintenance of long-term spatial memory or its subsequent retrieval.
记忆最初以不稳定的状态存储，并可能受到各种处理的影响，包括海马功能的破坏。我们在训练大鼠进行空间记忆任务（水迷宫）后，将一种钠通道阻断剂（或 CNQX）注入以可逆地抑制大鼠背侧海马 1 周。之前使用常规损伤的研究已经证实，背侧海马对于该任务中的记忆获得和表达都是必不可少的。本研究中的问题是，训练后背侧海马神经元活动的慢性破坏是否会消除记忆，或者记忆是否会在海马活动的延长破坏后存活。正如早期工作所预期的那样，我们发现在此期间的灌注期，表现受损。关键测试发生在损伤逆转后的 1 周。我们发现，水迷宫的保留恢复到控制水平。因此，训练后持续的海马活动对于长期空间记忆的维持或随后的检索并不是必需的。
