Fantini Marco, Zuliani Valentina, Spotti Mario A, Rivara Mirko
Dipartimento Farmaceutico, Università degli Studi di Parma, Parma, Italy.
J Comb Chem. 2010 Jan-Feb;12(1):181-5. doi: 10.1021/cc900152y.
A simple and efficient microwave assisted synthesis of imidazobenzoxazines, imidazobenzoxazin-5-ones, and imidazobenzoxazin-5-thiones with broad chemistry scope is described. The molecules were prepared both under conventional as well as microwave heating conditions, to provide in high yields with clean and scalable reactions a small library of imidazole-based privileged structures for drug discovery.
本文描述了一种简单高效的微波辅助合成咪唑并苯并恶嗪、咪唑并苯并恶嗪-5-酮和咪唑并苯并恶嗪-5-硫酮的方法,该方法具有广泛的化学适用范围。这些分子在常规加热和微波加热条件下均能制备,通过清洁且可扩展的反应以高产率提供了一个用于药物发现的基于咪唑的特权结构小型库。