Radi Marco, Botta Lorenzo, Casaluce Gianni, Bernardini Martina, Botta Maurizio
Dipartimento Farmaco Chimico Tecnologico, University of Siena, Siena, Italy.
J Comb Chem. 2010 Jan-Feb;12(1):200-5. doi: 10.1021/cc9001789.
A fast and efficient protocol for the generation of substituted 5-arylidene rhodanines in a sequential one-pot two-step process combining the "Holmberg method" and the Knoevenagel condensation under microwave-assisted conditions has been developed. The final compounds 11a-k have been obtained in high yield and purity after a simple precipitation from methanol, making this procedure facile, practical, and rapid to execute.
已开发出一种快速高效的方法，在微波辅助条件下，通过将“霍尔姆贝里方法”与克诺维纳格尔缩合相结合的连续一锅两步法来生成取代的5-亚芳基绕丹宁。最终化合物11a - k通过从甲醇中简单沉淀后，以高收率和纯度获得，使得该方法操作简便、实用且快速。
