用于微波辅助合成高官能化若丹宁衍生物的实用一锅两步法方案。

Practical one-pot two-step protocol for the microwave-assisted synthesis of highly functionalized rhodanine derivatives.

作者信息

Radi Marco, Botta Lorenzo, Casaluce Gianni, Bernardini Martina, Botta Maurizio

机构信息

Dipartimento Farmaco Chimico Tecnologico, University of Siena, Siena, Italy.

出版信息

J Comb Chem. 2010 Jan-Feb;12(1):200-5. doi: 10.1021/cc9001789.

DOI:10.1021/cc9001789

PMID:20028090

Abstract

A fast and efficient protocol for the generation of substituted 5-arylidene rhodanines in a sequential one-pot two-step process combining the "Holmberg method" and the Knoevenagel condensation under microwave-assisted conditions has been developed. The final compounds 11a-k have been obtained in high yield and purity after a simple precipitation from methanol, making this procedure facile, practical, and rapid to execute.

摘要

已开发出一种快速高效的方法，在微波辅助条件下，通过将“霍尔姆贝里方法”与克诺维纳格尔缩合相结合的连续一锅两步法来生成取代的5-亚芳基绕丹宁。最终化合物11a - k通过从甲醇中简单沉淀后，以高收率和纯度获得，使得该方法操作简便、实用且快速。