与AMPA型谷氨酸受体1（GluR1）的相互作用可能会影响米诺环素在肌萎缩侧索硬化症（ALS）中的治疗效果。
Interactions with GluR1 AMPA receptors could influence the therapeutic usefulness of minocycline in ALS.
作者信息
Manev Hari, Manev Radmila
机构信息
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, Illinois 60612, USA.
出版信息
Amyotroph Lateral Scler. 2009 Oct-Dec;10(5-6):416-7. doi: 10.3109/17482960802702288.
PMID:19922133
Abstract
Despite the beneficial effects of minocycline seen in animal models of ALS, initial clinical trials of minocycline in ALS patients failed to support its expected therapeutic usefulness. Here we discuss new results from recent preclinical studies of the molecular neuronal effects of minocycline pertinent for better understanding of the therapeutic potential of this antibiotic.
摘要
尽管米诺环素在肌萎缩侧索硬化症（ALS）动物模型中显示出有益效果，但米诺环素在ALS患者中的初步临床试验未能证实其预期的治疗效用。在此，我们讨论了近期临床前研究中关于米诺环素对神经元分子作用的新结果，这有助于更好地理解这种抗生素的治疗潜力。
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