米诺环素神经保护作用的前景。
Prospects for minocycline neuroprotection.
作者信息
Plane Jennifer M, Shen Yan, Pleasure David E, Deng Wenbin
机构信息
Department of Cell Biology and Human Anatomy, University of California, Davis, Sacramento, 95817, USA.
出版信息
Arch Neurol. 2010 Dec;67(12):1442-8. doi: 10.1001/archneurol.2010.191. Epub 2010 Aug 9.
Abstract
Minocycline is a clinically available antibiotic and anti-inflammatory drug that also demonstrates neuroprotective properties in a variety of experimental models of neurological diseases. There have thus far been more than 300 publications on minocycline neuroprotection, including a growing number of human studies. Our objective is to critically review the biological basis and translational potential of this action of minocycline on the nervous system.
摘要
米诺环素是一种临床可用的抗生素和抗炎药，在多种神经疾病实验模型中也表现出神经保护特性。迄今为止，关于米诺环素神经保护作用的出版物已超过300篇，其中包括越来越多的人体研究。我们的目标是严格审查米诺环素对神经系统这一作用的生物学基础和转化潜力。
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