生物胺的脑代谢研究。
Studies on brain metabolism of biogenic amines.
作者信息
Schacht U, Leven M, Bäcker G
出版信息
Br J Clin Pharmacol. 1977;4Suppl 2(Suppl 2):77S-87S. doi: 10.1111/j.1365-2125.1977.tb05763.x.
Abstract
- In vitro models (synaptosones, electrically stimulated brain slices and monoamine oxidase (MAO) preparations have been used to identify the sites of action of nomifensine on brain monoamine metabolism. 2. Nomifensine potentiates neurotransmission in noradrenergic and dopaminergic synapses by blocking catecholamine uptake. 3. Nomifensine does not inhibit MAO and does not enhance the release of biogenic amines. 4. Studies on electrically stimulated brain slices suggest that nomifensine does not directly stimulate dopamine (DA) nor noradrenaline (NA) receptor sites. 5. 5-Hydroxytryptamine (5-HT) uptake is not inhibited at "therapeutic" concentrations of nomifensine. 6. Nomifensine differs from the tricyclic antidepressants by virtue of its effect on the dopaminergic system.
摘要
- 体外模型（突触体、电刺激脑片和单胺氧化酶（MAO）制剂）已被用于确定诺米芬辛对脑单胺代谢的作用位点。2. 诺米芬辛通过阻断儿茶酚胺摄取增强去甲肾上腺素能和多巴胺能突触中的神经传递。3. 诺米芬辛不抑制MAO，也不增强生物胺的释放。4. 对电刺激脑片的研究表明，诺米芬辛不直接刺激多巴胺（DA）或去甲肾上腺素（NA）受体位点。5. 在诺米芬辛的“治疗”浓度下，5-羟色胺（5-HT）摄取未受抑制。6. 诺米芬辛因其对多巴胺能系统的作用而与三环类抗抑郁药不同。
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