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生物胺的脑代谢研究。

Studies on brain metabolism of biogenic amines.

作者信息

Schacht U, Leven M, Bäcker G

出版信息

Br J Clin Pharmacol. 1977;4Suppl 2(Suppl 2):77S-87S. doi: 10.1111/j.1365-2125.1977.tb05763.x.

DOI:10.1111/j.1365-2125.1977.tb05763.x
PMID:199222
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1429133/
Abstract
  1. In vitro models (synaptosones, electrically stimulated brain slices and monoamine oxidase (MAO) preparations have been used to identify the sites of action of nomifensine on brain monoamine metabolism. 2. Nomifensine potentiates neurotransmission in noradrenergic and dopaminergic synapses by blocking catecholamine uptake. 3. Nomifensine does not inhibit MAO and does not enhance the release of biogenic amines. 4. Studies on electrically stimulated brain slices suggest that nomifensine does not directly stimulate dopamine (DA) nor noradrenaline (NA) receptor sites. 5. 5-Hydroxytryptamine (5-HT) uptake is not inhibited at "therapeutic" concentrations of nomifensine. 6. Nomifensine differs from the tricyclic antidepressants by virtue of its effect on the dopaminergic system.
摘要
  1. 体外模型（突触体、电刺激脑片和单胺氧化酶（MAO）制剂）已被用于确定诺米芬辛对脑单胺代谢的作用位点。2. 诺米芬辛通过阻断儿茶酚胺摄取增强去甲肾上腺素能和多巴胺能突触中的神经传递。3. 诺米芬辛不抑制MAO，也不增强生物胺的释放。4. 对电刺激脑片的研究表明，诺米芬辛不直接刺激多巴胺（DA）或去甲肾上腺素（NA）受体位点。5. 在诺米芬辛的“治疗”浓度下，5-羟色胺（5-HT）摄取未受抑制。6. 诺米芬辛因其对多巴胺能系统的作用而与三环类抗抑郁药不同。

相似文献

1
Studies on brain metabolism of biogenic amines.生物胺的脑代谢研究。
Br J Clin Pharmacol. 1977;4Suppl 2(Suppl 2):77S-87S. doi: 10.1111/j.1365-2125.1977.tb05763.x.
2
Nomifensine and its derivatives as possible tools for studying amine uptake.诺米芬辛及其衍生物作为研究胺摄取的可能工具。
Eur J Pharmacol. 1977 Mar 21;42(2):101-6. doi: 10.1016/0014-2999(77)90348-x.
3
False labelling of dopaminergic terminals in the rabbit caudate nucleus: uptake and release of [3H]-5-hydroxytryptamine.家兔尾状核中多巴胺能终末的错误标记：[3H]-5-羟色胺的摄取与释放
Br J Pharmacol. 1986 Jul;88(3):677-84. doi: 10.1111/j.1476-5381.1986.tb10250.x.
4
Inhibition of in vitro amine uptake into rat brain synaptosomes after in vivo administration of antidepressants.体内给予抗抑郁药后对大鼠脑突触体体外胺摄取的抑制作用。
Eur J Pharmacol. 1983 Nov 25;95(3-4):305-9. doi: 10.1016/0014-2999(83)90652-0.
5
Effect of nomifensine (HOE 984), a new antidepressant, on uptake of noradrenaline and serotonin and on release of noradrenaline in rat brain synaptosomes.新型抗抑郁药诺米芬辛（HOE 984）对大鼠脑突触体中去甲肾上腺素和5-羟色胺摄取及去甲肾上腺素释放的影响。
Biochem Pharmacol. 1974 Dec 15;23(24):3413-22. doi: 10.1016/0006-2952(74)90344-x.
6
Stereoselective inhibition of synaptosomal catecholamine uptake by nomifensine.诺米芬辛对突触体儿茶酚胺摄取的立体选择性抑制作用。
Eur J Pharmacol. 1984 Feb 17;98(2):275-7. doi: 10.1016/0014-2999(84)90601-0.
7
Different effects of serotonin (5-HT) uptake blockers in caudate nucleus and hippocampus of the rabbit: role of monoamine oxidase in dopaminergic terminals.血清素（5-羟色胺，5-HT）摄取阻滞剂对兔尾状核和海马的不同作用：单胺氧化酶在多巴胺能终末的作用
Psychopharmacology (Berl). 1992;106(1):118-26. doi: 10.1007/BF02253598.
8
Nomifensine: A review of its pharmacological properties and therapeutic efficacy in depressive illness.诺米芬辛：其药理特性及对抑郁症治疗效果的综述
Drugs. 1979 Jul;18(1):1-24. doi: 10.2165/00003495-197918010-00001.
9
Nomifensine and central monoamine neurons: histofluorescence studies.
Pol J Pharmacol Pharm. 1977 Sep-Oct;29(5):509-19.
10
Dopaminergic properties of nomifensine.诺米芬辛的多巴胺能特性。
Pharmacol Biochem Behav. 1982 Nov;17(5):951-4. doi: 10.1016/0091-3057(82)90478-6.

引用本文的文献

1
Inhibition of potassium-stimulated release of [3H]dopamine from rat striata as a result of prior exposure to cocaine, nomifensine, or mazindol.
Neurochem Res. 1980 Mar;5(3):345-9. doi: 10.1007/BF00964622.
2
A comparison of the pharmacodynamic profiles of nomifensine and amitriptyline in normal subjects.正常受试者中诺米芬辛与阿米替林药效学特征的比较。
Br J Clin Pharmacol. 1980 Mar;9(3):247-53. doi: 10.1111/j.1365-2125.1980.tb04834.x.
3
Nomifensine: effect in Parkinsonian patients not receiving levodopa.诺米芬辛：对未接受左旋多巴治疗的帕金森病患者的作用。
J Neurol Neurosurg Psychiatry. 1981 Apr;44(4):352-4. doi: 10.1136/jnnp.44.4.352.
4
Attenuated response to nomifensine in rats during a swim test following lesion of the habenula complex.在缰核复合体损伤后的游泳试验中，大鼠对诺米芬辛的反应减弱。
Psychopharmacology (Berl). 1985;87(1):81-5. doi: 10.1007/BF00431783.
5
Relationship between sensorimotor neglect and the specificity, degree and locus of mesotelencephalic dopaminergic cell loss following 6-hydroxydopamine.6-羟基多巴胺诱导的感觉运动忽视与中脑多巴胺能细胞丧失的特异性、程度及部位之间的关系
Psychopharmacology (Berl). 1985;85(1):115-22. doi: 10.1007/BF00427334.
6
Interaction of alcohol with maprotiline or nomifensine: echocardiographic and psychometric effects.酒精与马普替林或诺米芬辛的相互作用：超声心动图和心理测量学效应。
Eur J Clin Pharmacol. 1988;35(6):593-9. doi: 10.1007/BF00637594.

本文引用的文献

1
Regional differences in H3-norepinephrine and H3-dopamine uptake into rat brain homogenates.大鼠脑匀浆中H3-去甲肾上腺素和H3-多巴胺摄取的区域差异。
J Pharmacol Exp Ther. 1969 Jan;165(1):78-86.
2
Catecholamine uptake by synaptosomes from rat brain. Structure-activity relationships of drugs with differential effects on dopamine and norepinephrine neurons.大鼠脑突触体对儿茶酚胺的摄取。对多巴胺能和去甲肾上腺素能神经元有不同作用的药物的构效关系。
Mol Pharmacol. 1971 Jan;7(1):66-80.
3
Drug-induced changes in the release of ( 3 H)-noradrenaline from field stimulated rat iris.药物诱导的大鼠虹膜经场刺激后（3H）-去甲肾上腺素释放的变化
Br J Pharmacol. 1971 Sep;43(1):97-106. doi: 10.1111/j.1476-5381.1971.tb07160.x.
4
Stereoselectivity of catecholamine uptake by brain synaptosomes: studies with ephedrine, methylphenidate and phenyl-2-piperidyl carbinol.脑突触体对儿茶酚胺摄取的立体选择性：麻黄碱、哌醋甲酯和苯基-2-哌啶基甲醇的研究
J Pharmacol Exp Ther. 1972 Oct;183(1):103-16.
5
Effect of thymoleptics on fenfluramine-induced depletion of brain serotonin in rats.
Eur J Pharmacol. 1973 Nov;24(2):205-10. doi: 10.1016/0014-2999(73)90073-3.
6
An in vitro model for the study of psychotropic drugs and as a criterion of antidepressant activity.
Biochem Pharmacol. 1973 Jan 1;22(1):73-84. doi: 10.1016/0006-2952(73)90256-6.
7
8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline, a new antidepressant.8-氨基-2-甲基-4-苯基-1,2,3,4-四氢异喹啉，一种新型抗抑郁药。
Arzneimittelforschung. 1973 Jan;23(1):45-50.
8
Presynaptic regulation of catecholamine release.儿茶酚胺释放的突触前调节。
Biochem Pharmacol. 1974 Jul 1;23(13):1793-800. doi: 10.1016/0006-2952(74)90187-7.
9
Effect of nomifensine (HOE 984), a new antidepressant, on uptake of noradrenaline and serotonin and on release of noradrenaline in rat brain synaptosomes.新型抗抑郁药诺米芬辛（HOE 984）对大鼠脑突触体中去甲肾上腺素和5-羟色胺摄取及去甲肾上腺素释放的影响。
Biochem Pharmacol. 1974 Dec 15;23(24):3413-22. doi: 10.1016/0006-2952(74)90344-x.
10
Effect of nomifensine on motor activity, dopamine turnover rate and cyclic 3',5;-adenosine monophosphate concentrations of rat striatum.去甲丙咪嗪对大鼠纹状体运动活性、多巴胺周转率及环磷腺苷浓度的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1974;286(1):49-63. doi: 10.1007/BF00499104.