Strömberg C, Suokas A, Seppälä T
Department of Pharmacology and Toxicology, University of Helsinki, Finland.
Eur J Clin Pharmacol. 1988;35(6):593-9. doi: 10.1007/BF00637594.
Eight healthy volunteers received low doses of maprotiline and nomifensine up to 50 mg b.d. for 15 days in a double-blind, cross-over, placebo controlled study, during which echocardiography and psychomotor testing were carried out before and after the intake of alcohol 1 g/kg. Maprotiline increased heart rate and cardiac output and reduced peripheral resistance compared to placebo and nomifensine. Nomifensine alone was associated with a slight decrease in heart rate. Alcohol alone caused a significant increase in diastolic blood pressure, but did not otherwise modify the cardiovascular measures. The antidepressants did not augment the effects of alcohol. Antidepressants alone had no effect on psychomotor skills, but alcohol always impaired performance. No additional effects of alcohol were produced by the antidepressants. It appears that practically important peripheral or central consequences are unlikely to follow drinking a moderate amount of alcohol during regular therapy with low therapeutic doses of catecholamine reuptake inhibiting antidepressants. Experimental studies of the interaction of antidepressants and alcohol in patients with chronic heart disease seem to be justified.
在一项双盲、交叉、安慰剂对照研究中，8名健康志愿者接受了低剂量的麦普替林和诺米芬辛，剂量高达每日两次、每次50毫克，持续15天。在此期间，在摄入1克/千克酒精前后进行了超声心动图检查和精神运动测试。与安慰剂和诺米芬辛相比，麦普替林可增加心率和心输出量，并降低外周阻力。单独使用诺米芬辛会使心率略有下降。单独饮酒会导致舒张压显著升高，但未对其他心血管指标产生影响。抗抑郁药并未增强酒精的作用。单独使用抗抑郁药对精神运动技能没有影响，但酒精总会损害表现。抗抑郁药未产生酒精的额外作用。看来，在使用低治疗剂量的儿茶酚胺再摄取抑制抗抑郁药进行常规治疗期间，饮用适量酒精不太可能产生实际重要的外周或中枢影响。对慢性心脏病患者抗抑郁药与酒精相互作用的实验研究似乎是合理的。
