Department of Histology and Embryology, Weifang Medical College, Weifang, China.
Int J Neurosci. 2009;119(8):1076-90. doi: 10.1080/00207450802330504.
Neural tube defects (NTDs) are a group of severe congenital malformations resulting from the failure of neurulation. Genes influencing neurulation have been investigated for their contribution to NTDs. Ribosomal protein (Rp) is an abundant and belongs to a high conservative gene family, which has the complex task of coordinating protein biosynthesis in order to maintain cell homeostasis and survival. However, the mechanisms of Rp in the NTDs are unknown. Understanding the mechanisms will lead to new insights into NTDs. In this report, we constructed a cDNA library from neural tube of golden hamster and screened the cDNA library by a subsection screening method (SSS). Our results demonstrate a possible essential role of the RPL30 cDNA gene during neurulation and in the risk of NTDs. Our study also suggests that another gene, HMGB1, may be significantly associated with neurulation and the risk of NTDs.
神经管缺陷（NTDs）是一组严重的先天性畸形，是由于神经管闭合失败引起的。影响神经管闭合的基因已被研究其对 NTDs 的贡献。核糖体蛋白（Rp）是一种丰富的，属于高度保守的基因家族，其具有协调蛋白质生物合成的复杂任务，以维持细胞内环境平衡和生存。然而，Rp 在 NTDs 中的机制尚不清楚。了解这些机制将为 NTDs 提供新的见解。在本报告中，我们从金黄地鼠的神经管中构建了 cDNA 文库，并通过亚段筛选法（SSS）筛选 cDNA 文库。我们的结果表明，RPL30 cDNA 基因在神经管闭合和 NTDs 风险中可能起着重要作用。我们的研究还表明，另一个基因 HMGB1 可能与神经管闭合和 NTDs 风险显著相关。
