Facultad de Ciencias Exactas Físicas y Naturales, Universidad Nacional de Córdoba, Vélez Sarsfield, 299X5000JJC Córdoba, Argentina.
Int J Neurosci. 2009;119(9):1319-36. doi: 10.1080/00207450902931847.
The present study investigated the effect of early maternal separation on anxiety and hypophyso-adrenal system activity to anterodorsal thalamic nuclei (ADTN) lesion in male rats as adults in order to compare this with previous results with female rats. During the first 3 weeks of life, male rats were isolated 4.5 hr daily and tested as adults. Thirty days after ADTN lesion we found that adrenocorticotropic hormone (ACTH) plasma levels were affected neither by maternal separation nor by ADTN lesion. Plasma corticosterone (CORT) concentration was increased with lesion of the ADTN in maternally separated rats. A significant increase in plasma catecholamine concentration was induced by early maternal separation. In ADTN-lesioned rats, plasma norepinephrine (NE) concentration was significantly lower than in the respective sham-lesioned groups. In terms of anxiety, there were no significant effects of early experience. However, the ADTN lesion tended to decrease anxiety-related behavior.
本研究旨在探讨早期母婴分离对雄性大鼠成年后焦虑和垂体肾上腺系统活动对前背丘脑核（ADTN）损伤的影响，以便与以前对雌性大鼠的研究结果进行比较。在生命的头 3 周内，雄性大鼠每天被分离 4.5 小时，并在成年后进行测试。在 ADTN 损伤后 30 天，我们发现促肾上腺皮质激素（ACTH）的血浆水平既不受母婴分离的影响，也不受 ADTN 损伤的影响。在母婴分离的大鼠中，血浆皮质酮（CORT）浓度因 ADTN 损伤而增加。早期母婴分离可诱导血浆儿茶酚胺浓度显著升高。在 ADTN 损伤的大鼠中，血浆去甲肾上腺素（NE）浓度明显低于相应的假损伤组。在焦虑方面，早期经历没有显著影响。然而，ADTN 损伤往往会降低与焦虑相关的行为。
