基底及应激状态下丘脑前背侧核对促肾上腺皮质激素释放的影响。

Influence of anterodorsal thalami nuclei on ACTH release under basal and stressful conditions.

作者信息

Suárez M M, Perassi N I

机构信息

Cátedra de Fisiología Animal, Facultad de Ciencias Exactas, Físicas y Naturales, Instituto de Fisiología, Universidad Nacional de Córdoba, Santa Rosa, Argentina.

出版信息

Physiol Behav. 1997 Aug;62(2):373-7. doi: 10.1016/s0031-9384(97)00032-2.

DOI:10.1016/s0031-9384(97)00032-2

PMID:9251982

Abstract

Experiments were carried out to evaluate the effect of anterodorsal thalami nuclei (ADTN) lesions on plasma ACTH and corticosterone (C), in unstressed and stressed rats. Thirty days after lesion, basal values of plasma ACTH, plasma and adrenal C were significantly higher than those in sham lesioned rats (p < 0.05: p < 0.05; p < 0.01, respectively). Chronic stress (forced immobilization, 15 min/day, during 12 days) in sham-operated animals produced a significat increase in ACTH (p < 0.05) and plasma C (p < 0.05), and a slight decrease in adrenal C, as compared to unstressed rats. In lesioned stressed rats, plasma ACTH was below that found in unstressed lesioned and in sham-lesioned stressed rats (p < 0.05). Variations of plasma C concentrations of stressed lesioned rats were not significant. The adrenal glands of stressed lesioned rats showed a significantly lower content of C than that in unstressed lesioned rats (p < 0.005). It is concluded that ADTN in rats may play a significant role in regulating the hipophyso-adrenal system.

摘要

开展实验以评估丘脑前背核（ADTN）损伤对未应激和应激大鼠血浆促肾上腺皮质激素（ACTH）和皮质酮（C）的影响。损伤后30天，血浆ACTH、血浆和肾上腺C的基础值显著高于假手术损伤大鼠（分别为p < 0.05；p < 0.05；p < 0.01）。与未应激大鼠相比，假手术动物的慢性应激（强迫固定，每天15分钟，持续12天）使ACTH（p < 0.05）和血浆C（p < 0.05）显著增加，肾上腺C略有下降。在损伤的应激大鼠中，血浆ACTH低于未应激损伤大鼠和假手术损伤应激大鼠（p < 0.05）。损伤的应激大鼠血浆C浓度变化不显著。损伤的应激大鼠的肾上腺C含量显著低于未应激损伤大鼠（p < 0.005）。结论是，大鼠的ADTN可能在调节垂体 - 肾上腺系统中起重要作用。