Department of Pharmacology and Neuroscience, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
Int J Neurosci. 2009;119(9):1362-83. doi: 10.1080/00207450902955770.
Dynorphin (DYN) fragments are the members of the endogenous opioid system and postulated ligands for the opioid receptors. Infusion of DYN(1-17) fragment into the rat dorsal striatum caused a significant increase in acetylcholine and decrease in dopamine overflow. Contrary to this, infusions of DYN(2-17) fragment into the rat dorsal striatum caused a significant increase in dopamine and decrease in acetylcholine overflow. Intrastriatal infusions of different doses of the acetylcholinesterase blocker, neostigmine, augmented acetylcholine and inhibited dopamine overflow in a dose-dependent manner. The opposing responses of the DYN fragments suggest that the N-terminal residue plays a key role in presynaptic neuromodulation.
脑啡肽（DYN）片段是内源性阿片系统的成员，也是阿片受体的假定配体。将 DYN（1-17）片段注入大鼠背侧纹状体可显著增加乙酰胆碱并减少多巴胺溢出。与此相反，将 DYN（2-17）片段注入大鼠背侧纹状体可显著增加多巴胺并减少乙酰胆碱溢出。向纹状体中注入不同剂量的乙酰胆碱酯酶抑制剂新斯的明可增加乙酰胆碱并抑制多巴胺溢出，呈剂量依赖性。DYN 片段的相反反应表明，N 端残基在突触前神经调节中起着关键作用。
