Meyer M E
Department of Psychology, University of Florida, Gainesville 32611.
Pharmacol Biochem Behav. 1993 Feb;44(2):329-32. doi: 10.1016/0091-3057(93)90469-a.
The effects of bilateral intrastriatal injections (2.0 micrograms/side) of Dynorphin A 1-17 (Dyn A 1-17) and Dynorphin A 1-8 (Dyn A 1-8) and their related nonopioid fragments upon the dorsal immobility response (DIR) over a 1-h time course were investigated. Dyn A 1-17 and Dyn A 2-17 potentiated the duration of the DIR 5 min postinjection, whereas Dyn A 1-8 and Dyn A 2-8 potentiated the DIR duration at each time point over the hour with their greatest effect at 15 min. An SC injection of 4 mg/kg naloxone 15 min prior to central injections blocked the potentiation of the DIR effects of Dyn A.
研究了双侧纹状体内注射强啡肽A 1-17（Dyn A 1-17）和强啡肽A 1-8（Dyn A 1-8）及其相关非阿片肽片段（2.0微克/侧）在1小时时间进程中对背侧不动反应（DIR）的影响。Dyn A 1-17和Dyn A 2-17在注射后5分钟增强了DIR的持续时间，而Dyn A 1-8和Dyn A 2-8在1小时内的每个时间点都增强了DIR持续时间，在15分钟时效果最为显著。在中枢注射前15分钟皮下注射4毫克/千克纳洛酮可阻断Dyn A对DIR效应的增强作用。
