Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany.
Int J Neurosci. 2009;119(10):1548-71. doi: 10.1080/00207450802323947.
We investigated longitudinally the behavioral development in the rat following exposure to beta-agonists and glucocorticoids (GC). Neonatal rats received either 1 mg/kg fenoterol (FEN), 0.3 mg/kg betamethasone (BET), or saline (SAL). Weanling and young adult rats were tested in the open field, the elevated-plus maze, and the water maze. FEN-treated as well as BET-treated animals displayed increased anxiety-like behavior. Furthermore, BET-treated adult animals showed a reduced locomotor activity. An enhanced 24-h memory in the water maze in both treatment groups may be facilitated by emotional arousal due to the increased anxiety levels. The possible neurobiological underpinnings are discussed in detail.
我们研究了β-激动剂和糖皮质激素（GC）暴露后大鼠的行为发育情况。新生大鼠接受 1mg/kg 非诺特罗（FEN）、0.3mg/kg 倍他米松（BET）或生理盐水（SAL）。幼鼠和成年大鼠在旷场、高架十字迷宫和水迷宫中进行测试。FEN 处理和 BET 处理的动物表现出焦虑样行为增加。此外，BET 处理的成年动物的运动活性降低。由于焦虑水平增加，两个治疗组在水迷宫中的 24 小时记忆增强可能是由情绪唤醒促进的。详细讨论了可能的神经生物学基础。
