希腊人群喉鳞状细胞癌中GSTT1、GSTM1、GSTM3和NAT2基因多态性
GSTT1, GSTM1, GSTM3 and NAT2 polymorphisms in laryngeal squamous cell carcinoma in a Greek population.
作者信息
Chatzimichalis M, Xenellis J, Tzagaroulakis A, Sarof P, Banis K, Gazouli M, Bibas A
机构信息
Department of Otolaryngology Head and Neck Surgery, Metaxa Anticancer Hospital, Piraeus, Greece.
出版信息
J Laryngol Otol. 2010 Mar;124(3):318-23. doi: 10.1017/S002221510999154X. Epub 2009 Nov 19.
OBJECTIVE
It is well known that laryngeal squamous cell carcinoma is strongly related to tobacco and alcohol consumption. Accumulating evidence suggests that alterations of detoxification enzymes, such as glutathione S-transferases and N-acetyltransferases, influence the risk of cancers associated with tobacco smoke and alcohol.
METHODS
This was a retrospective case-control study. The study group consisted of 88 Greek patients with laryngeal squamous cell carcinoma; there were also 102 control subjects. Frequencies of the genotypes GSTT1, GSTM1, GSTM3 and NAT2 were evaluated by polymerase chain reaction restriction fragment polymorphism.
RESULTS
The distribution of overall genotypes was 55.68 per cent rapid acetylator and 44.32 per cent slow acetylator in patients, and 36.27 per cent rapid acetylator and 63.72 per cent slow acetylator in controls. The odds ratio for rapid acetylator status in cases versus controls was 2.207 (95 per cent confidence interval 1.23-3.95, p = 0.0087).
CONCLUSION
This study demonstrated a significant relationship between rapid acetylator genotypes and laryngeal squamous cell carcinoma in a Greek population.
目的
众所周知，喉鳞状细胞癌与烟草和酒精消费密切相关。越来越多的证据表明，解毒酶的改变，如谷胱甘肽S-转移酶和N-乙酰转移酶，会影响与烟草烟雾和酒精相关的癌症风险。
方法
这是一项回顾性病例对照研究。研究组由88名希腊喉鳞状细胞癌患者组成；还有102名对照受试者。通过聚合酶链反应限制性片段多态性评估GSTT1、GSTM1、GSTM3和NAT2基因型的频率。
结果
患者中总体基因型的分布为55.68%快速乙酰化者和44.32%缓慢乙酰化者，对照组中为36.27%快速乙酰化者和63.72%缓慢乙酰化者。病例组与对照组快速乙酰化状态的比值比为2.207（95%置信区间1.23 - 3.95，p = 0.0087）。
结论
这项研究表明在希腊人群中快速乙酰化基因型与喉鳞状细胞癌之间存在显著关系。
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